The Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling (CHROMusTM) will develop fifty transgenic mouse lines designed for combinatorial crosses enabling the co-expression of sensors and effectors, or red and green Ca2+ sensors in interacting lineages. As such, the resource will enable researchers to conduct experiments not otherwise possible in a cost effective and highly efficient manner, facilitating the use of optical genetic tools and markedly accelerating scientific discovery. Additional lines of mice previously developed in the Kotlikoff laboratory that are useful in labeling cell lineages or are GECIs, will also be included under CHROMusTM
CHROMusTM is directed by Dr. Michael Kotlikoff, Cornell University. A Steering Committee consisting of eleven additional world renowned scientists expert in the fields of cardiac, vascular, lung and immuno biology as well as in fluorescent protein design, optogenetics and gene targeting will meet bi-annually to prioritize and review mouse lines.
Once created, mouse lines will be distributed by the resource initially and deposited with The Jackson Laboratory for further distribution.
Supported by: National Heart Lung and Blood Institute Grant # R24HL120847
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